{"id":109985,"date":"2018-03-20T23:05:00","date_gmt":"2018-03-20T20:05:00","guid":{"rendered":"http:\/\/acakuw.com\/?p=109985"},"modified":"2018-03-20T23:05:17","modified_gmt":"2018-03-20T20:05:17","slug":"109985-2","status":"publish","type":"post","link":"https:\/\/acakuw.com\/?p=109985","title":{"rendered":"\u0645\u062d\u0627\u0636\u0631\u0629 “\u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0645\u062c\u0647\u0631\u064a \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062d\u064a\u0651\u0629: \u0628\u0635\u064a\u0631\u0629 \u0645\u064f\u062c\u062f\u062f\u0629 \u062d\u0648\u0644 \u0628\u0644\u0639\u0645\u0629 \u0627\u0644\u0641\u0637\u0631\u064a\u0627\u062a \u0645\u0646 \u0645\u062e\u062a\u0644\u0641 \u0627\u0644\u0641\u0635\u0627\u0626\u0644” \u0628\u0643\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0648\u0645"},"content":{"rendered":"

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Live-cell imaging: insights into the phagocytosis of taxonomically diverse fungi<\/b><\/p>\n

Dr. Mohammed Jassim Haidar, a member of the faculty of biological sciences department, Faculty of Science, delivered a scientific lecture titled: <\/span>Live-cell imaging: insights into the phagocytosis of taxonomically diverse fungi<\/b><\/p>\n

Phagocytosis is a receptor-mediated process critical to innate immune clearance of pathogens. It proceeds in a regulated sequence of stages: (a) migration of phagocytes towards pathogens, (b) recognition of PAMPs and binding through PRRs, (c) engulfment and internalisation into phagosomes, (d) phagosome maturation, and (e) killing of pathogen or host cells. However, little is known about the role that individual receptors play in these discrete stages in the recognition of fungal cells. In a previous study, we found that dectin-2 deficiency impacted some but not all stages of macrophage-mediated phagocytosis of <\/span>Candida glabrata<\/span><\/i>. Because the C-type lectin receptor dectin-2 critically requires coupling to the FcR\u03b3 chain for signalling, we hypothesised that this coupling may be important for regulating phagocytosis of fungal cargo. To explore this in more detail, we examined how deficiency in FcR\u03b3 itself or two receptors to which it couples (dectin-2 and mincle) impacts phagocytosis of six fungal organisms representing three different fungal taxa. Our data show that deficiency in these proteins impairs macrophage migration, engulfment, and phagosome maturation, but not macrophage survival. Therefore, FcR\u03b3 engagement with selective C-type lectin receptors (CLRs) critically affects the spatio-temporal dynamics of fungal phagocytosis.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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